mTOR inhibitor 10 ( —— )

产品货号. M10850 CAS No. 1222999-54-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

mTOR inhibitor 10
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种新型有效、选择性 mTOR 抑制剂，对 mTORC1 的生化 IC50 为 21.7 nM。
产品描述

A novel potent, selective mTOR inhibitor with biochemical IC50 of 21.7 nM for mTORC1, exhibits cellular potency against mTOR with IC50 of 5 nM; displays >50-fold selectivity over PIKKs (hVSP34, PI3Ks, PI4K, etc.); exhibits significant inhibitory activity against the downstream targets of mTOR, S6K, and Akt, and blocks 80-90% phosphorylation of S6K (T389) and pAkt (S473) in liver and lung tissues, along with significantly improved mouse liver microsome stability and a longer in vivo half-life.
体外实验

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体内实验

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同义词

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通路

PI3K/Akt/mTOR signaling
靶点

mTOR
受体

mTOR
研究领域

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适应症

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CAS Number

1222999-54-3
分子量

683.735
分子式

C41H32F3N5O2
纯度

>98% (HPLC)
溶解度

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SMILES

CN1CCC(CC1)NC(=O)C2=CC=C(C=C2)C3=C(C=C(C=C3)N4C(=O)C=CC5=CN=C6C=CC(=CC6=C54)C7=CC8=CC=CC=C8N=C7)C(F)(F)F
化学全称

N-(1-methylpiperidin-4-yl)-4'-(2-oxo-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-1(2H)-yl)-2'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxamide